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Organ-Chips 201: The Importance of Flow, Stretch, and Stroma for in vitro Modeling

July 25, 2024
11:00 am — 12:00 pm EDT



In Organ-Chips 101, we provided an overview of microphysiological systems (MPS) and explained how Organ-Chips are helping bridge the gap between conventional in vitro models and human biology. In Organ-Chips 201, we will delve deeper into the technological advancements of Organ-on-a-Chip technology and how it vastly improves the human relevance of in vitro models. We will discuss advanced applications of Organ-Chips to further develop your understanding of MPS by focusing in on three core elements: flow, stretch, and heterogeneous cell-cell interactions.  

This webinar will feature high-impact case studies presented by Emulate’s Scientific Liaison team describing how each of these elements contributes to more powerful modeling capabilities and true-to-life human biology, including how:   

  • Continuous flow provided orders-of-magnitude more predictive insights into intestinal absorption of oral peptide formulations than static culture  
  • Episodic flow influenced endocervical vs. ectocervical tissue formation in a Cervix-Chip 
  • Applying cyclic stretch revealed previously undiscoverable mechanisms of Shigella infection in the colon 
  • Including stomal fibroblasts resulted in enhanced functionality of skin and alveolar tissue  
  • Manipulating epithelial-stromal interactions can help uncover mechanisms underlying cancer progression 

If you are familiar with Organ-on-a-Chip technology but want further insight into how it provides more in vivo-relevant data, this webinar is the perfect opportunity for you to graduate from the basics and gain a more functional understanding of how this technology is transforming in vitro modeling capabilities.