Accelerating Drug Development for Inflammatory Bowel Disease with Organ-Chips

Webinar Abstract

Inflammatory bowel disease (IBD) represents an enormous area of unmet medical need. Despite ~10 million people suffering from IBD globally, ~50% of patients fail to respond to on-market therapy, and ~90% fail to experience long-term remission.

The limited efficacy of IBD therapeutics is due in part to the limited human relevance of conventional preclinical models, which restrict researchers to studying just one aspect of IBD at a time. These models fail to accurately predict drug effects within the complex intestinal microenvironment, leading to high clinical trial failure rates.

It’s time for a human-centric approach to IBD drug discovery and development.

In this webinar, Marianne Kanellias discussed how researchers can use Emulate Organ-on-a-Chip technology to create a more representative and complex model of IBD pathogenesis. With the Emulate human Colon Intestine-Chip, researchers can recapitulate the inflammatory response of IBD—from immune cell vascular attachment, to migration, to downstream effector function and barrier damage—and evaluate the efficacy of anti-inflammatory therapeutics in a more human-relevant model of IBD.

Key highlights from this IBD webinar:

  • Common challenges in modeling inflammatory disease
  • Recreating gut- and inflammation-specific immune cell recruitment with the Colon Intestine-Chip
  • Evaluating clinically relevant IBD therapeutics across a range of mechanisms of action
  • A panel discussion and live Q&A with Marianne Kanellias and Chris Carman, PhD who led the development of the immune cell recruitment application for the Colon Intestine-Chip

For additional data, see the data in the inflammatory immune cell recruitment application note.