organ-Chip model

Brain-Chip

Study human physiology, disease, and drug effect in a comprehensive model of the neurovascular unit

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The Brain-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. As a Guided Model, Emulate offers guidelines and field scientist support for building a Brain-Chip using the Human Emulation System.

Fluorescence microscopy image of a human neuronal cell in the Brain-Chip.

Characterization

The most comprehensive human neurovascular unit model

The Brain-Chip is being designed to overcome the limitations of other methods and provide researchers a more physiologically relevant understanding of neurovascular unit physiology and disease. Unlike other in vitro models such as organoids and conventional cell cultures, this ‘Brain-on-a-Chip’ model will more closely recapitulate morphological and functional characteristics of cortical brain tissue, incorporating both neuronal cells and an endothelial-like barrier in a single model.

Benefits

Multicellular complexity to improve neuron function

Unlike conventional cell cultures with limited cell types, the Brain-Chip contains five human cell types: neurons, astrocytes, pericytes, microglia, and brain microvascular endothelial-like cells.

Stable functionality

Characteristic morphology, gene expression, and functionality can be maintained up to seven days of culture, unlike Transwell models which gradually lose functionality over this period.

A human-based model

Mitigate preclinical-to-clinical translational issues often seen in animal models.

Part of the Human Emulation System®

The Human Emulation System is comprised of instruments, consumables, and software in a flexible, open format. The user-friendly platform gives researchers a window into the inner workings of human biology.

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Get Started Today

Experience the predictive power of Organ-on-a-Chip technology.

Basic Research Kit

Includes chips and reagents for use with customer cell sourcing.